Chair, Department of Nutrition and Food Hygiene Director, Research Sharing Platform (Core Facilities) School of Public Health Nanjing Medical University
Office phone：025-86868465
钱旭，博士生导师
Xu Qian, MD, PhD
Research Interest
Cancer Metabolism: metabolite sensing in tumorigenesis
Education
Ø Nanjing Medical University, Pathology and Pathophysiology, PhD. Supervisor: Dr. Binghua Jiang. (2007.9-2013.7)
Ø China Pharmaceutical University, Department of Biological Engineering, B.S. (2003.9-2007.7)
Working
Ø Nanjing Medical University, School of Public Health, Professor. (2018.09 to present)
Ø University of Texas M.D. Anderson Cancer Center, Department of Neuro-Oncology, USA, Postdoctoral Fellowship, Supervisor: Dr. Zhimin Lu. (2013.12-2018.9)
Honors and Awards
Ø National Major Talent Project Class A Young Scholars (Young Thousand Talents)
Ø Jiangsu Specially-Appointed Professor
Ø Leader of Jiangsu Province Innovation and Entrepreneurship Team
Ongoing Research Projects
Ø PI, Mechanisms underlying EGFR/ASL-enhanced expression of promoter-mutant TERT in glioblastoma, The General Program of NSFC, 82072765
Ø PI, Mechanisms underlying PTEN cysteine-succination-regulated glioblastoma tumorigenesis. NSFC for Young Scholars, 81902817
Representative Papers The Past Five Years
# Co-first author, * Co-corresponding author
1. Ge X#, Li M#, Yin J, Shi Z, Fu Y, Zhao N, Chen H, Meng L, Li X, Hu Z, Zhao X*, Guo H*, Qian X*. Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type 2 papillary renal cell carcinoma. Mol Cell. 2022;82(7):1249-1260.e7. (IF = 19.328)
2. Li X#,*, Qian X#, Wang B, Xia Y, Zheng Y, Du L, Xu D, Xing D, DePinho RA, Lu Z*. Programmable base editing of mutated TERT promoter inhibits brain tumor growth. Nat Cell Biol. 2020;22(3):282-288. (IF = 20.042)
3. Qian X#,*, Li X#, Shi Z, Bai X, Xia Y, Zheng Y, Xu D, Chen F, You Y, Fang J, Hu Z, Zhou Q, Lu Z*. KDM3A senses oxygen availability to regulate PGC-1a-mediated mitochondrial biogenesis. Mol Cell. 2019;76(6):885-895.e7. (IF = 15.584)
4. Qian X#,*, Li X#, Shi Z, Xia Y, Cai Q, Xu D, Tan L, Du L, Zheng Y, Zhao D, Zhang C, Lorenzi PL, You Y, Jiang BH, Jiang T, Li H, Lu Z*. PTEN suppresses glycolysis by dephosphorylating and inhibiting autophosphorylated PGK1. Mol Cell. 2019;76(3):516-527.e7. (IF = 15.584)
5. Qian X#, Li X#, Tan L, Lee JH, Xia Y, Cai Q, Zheng Y, Wang H, Lorenzi PL, Lu Z. Conversion of PRPS hexamer to monomer by AMPK-mediated phosphorylation inhibits nucleotide synthesis in response to energy stress. Cancer Discov. 2018;8(1):94-107. (IF = 26.370)
6. Li X#, Qian X#, Jiang H, Xia Y, Zheng Y, Li J, Huang BJ, Fang J, Qian CN, Jiang T, Zeng YX, Lu Z. Nuclear PGK1 alleviates local ADP-dependent inhibition of CDC7 to promote DNA replication. Mol Cell. 2018;72(4):650-660.e8. (IF = 14.548)
7. Qian X, Li X, Cai Q, Zhang C, Yu Q, Jiang Y, Lee JH, Hawke D, Wang Y, Xia Y, Zheng Y, Jiang BH, Liu DX, Jiang T, Lu Z. Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy. Mol Cell. 2017;65(5):917-931.e6. (IF = 14.248)
