李忠，教授，博士生导师。是江苏省“青蓝工程”中青年学术带头人，现代毒理学省部共建教育部重点实验室成员，中国毒理学会食品毒理学专业委员会理事。2003-2005年，作为访问学者在美国 University of Illinois从事食品毒理学研究。先后主持国家“863”子课题、国家自然科学基金项目、教育部博士点基金、江苏省自然科学基金项目、省教育厅和省卫生厅重点项目；发表论文50余篇，其中SCI收录文章30余篇。2014年获国家教学成果二等奖。目前主要研究方向为营养毒理学与食品安全。
研究方向
1. 营养与肿瘤：研究膳食非营养素成分对肿瘤侵袭转移和血管生成的作用影响。
2. 营养毒理学：营养素的人体代谢产物对健康的影响，以及相关干预策略。
3. 食品安全：膳食来源植物雌激素的健康效应，探讨相关干预措施。
联系方式：电话：025-86868451；邮箱：Lz-ny@njmu.edu.cn
主要在研课题
1. ROS激活的RECK表遗传调控在27HC介导乳腺癌侵袭转移中的作用（国家自然科学基金项目2016）
2. 胆固醇代谢与肝纤维化（全球健康中心项目 2019）
代表性论著
1. 27-hydroxycholesterol-induced EndMT acts via STAT3 signaling to promote breast cancer cell migration by altering the tumor microenvironment. Cancer Biol Med. 2020; 17:88-100.
2. Resveratrol inhibits the proliferation of estrogen receptor-positive breast cancer cells by suppressing EZH2 through the modulation of ERK1/2 signaling. Cell Bio Toxicol2019;35(5):445-456.
3. Blocking of STAT-3/SREBP1-mediated glucose-lipid metabolism is involved in dietary phytoestrogen- inhibited ovariectomized-induced body weight gain in rats. J Nutr Biochem. 2018;61:17-23.
4. The repressive effect of miR-148a on Wnt/β-catenin signaling involved in Glabridin induced anti- angiogenesis in human breast cancer cells. BMC Cancer 2017;17:307.
5. Glabridin inhibits cancer stem cell-like properties of human breast cancer cells: an epigenetic regulation of miR-148a/ SMAD2 signaling. Mol Carcinog. 2016; 55(5): 929-940
6. Effectiveness of a public dietitian-led diabetes nutrition intervention on glycemic control in a community setting in China. Asia Pac J Clin Nutr. 2015; 24(3): 525-32.
7. Arsenic trioxide attenuates the invasion potential of human liver cancer cells through the demethylation-activated microRNA-491. Toxicol Lett, 2014, 227(2):75-83.
8. Arsenic induces functional re-expression of estrogen receptor α by demethylation of DNA in estrogen receptor-negative human breast cancer. PLoS one, 2012, 7(4): e35957.
9. Delayed activation of extracellular-signal regulated kinase (ERK1/2) is involved in genistein- and equol-induced cell proliferation and estrogen receptor α-mediated transcription in MCF-7 breast cancer cells. J Nutr Biochem. 2010, 21: 390-396.
10. Caffeine overcomes genistein-induced G2/M cell cycle arrest in breast cancer cells. Nutr Cancer. 2008, 60: 382-388.