周建伟, 医学博士,职业医学与环境卫生学系教授(二级/特聘教授),博士生导师。
学术兼职:包括中国毒理学会副理事长、江苏省毒理学会理事长;Current Cancer Drug Target(CCDT)和Journal of Toxicology Research (JTR)顾问;Journal of Toxicology and Environmental Health(JTEH), B副主编,Journal of Biomedical Research (JBR)编委;长期从事环境与肿瘤关系的教学和转化医学科研工作,探索JWA基因的结构功能以及与人类重大疾病关系。曾主持国家自然科学基金项目11项,包括面上、重点、重大研究计划、疾病动物模型和重点国际合作项目,科技部973预研项目等。
主要荣誉:十大体育外围平台网址首届教学名师,江苏省有突出贡献的中青年专家、江苏省首批中青年科技领军人才,江苏省优秀教育工作者、江苏省优秀科技工作者、享受国务院政府特殊津贴专家等。
研究方向:环境应答基因JWA与炎症、衰老和肿瘤关系的转化医学研究。
联系方式:南京市江宁区龙眠大道101号,十大体育外围平台网址至诚楼十大体育外围平台网址248室; 电话:02586868421;电子邮件:jwzhou@njmu.edu.cn
目前主持的科研项目:
1.国家自然科学基金面上项目(81973156)JWA基因缺失致小肠发育不良在衰老中的作用及防治,2020-2023,55万元;
国家自然科学基金委面上项目(81673219)环境应答基因JWA缺陷所致小鼠早衰的动物模型研究,2017-2020, 85万元;
2. 国家自然科学基金委重点国际合作与交流项目(81520108027)基于JWA/MDM2调控网络的抑制胃癌/黑色素瘤转移序贯策略研究,2016-2020,235万元。
代表性论文:
1. Cui JH, Shu CJ, Xu J, Chen DY, Li J, Ding K, Chen MJ, Li AP, He JD, Shu YQ, Yang LQ, Zhang RW, Zhou JW. JP1 suppresses proliferation and metastasis of melanoma through MEK1/2 mediated NEDD4L-SP1-Integrin αvβ3 signaling. Theranostics, 2020, doi:10.7150/thno.45843.
2. Chen JJ, Ren YL, Shu CJ, Zhang Y, Chen MJ, Xu J, Li J, Li AP, Chen DY, He JD, Shu YQ, Zhou JW. JP3, an antiangiogenic peptide, inhibits growth and metastasis of gastric cancer through TRIM25/SP1/MMP2 axis. J Exp Clin Cancer Res, 2020, doi: 10.1186/s13046-020-01617-813046-2020-1617
3. Wang Z, Gong Y, Peng B, Shi R, Fan D, Zhao H, Zhu M, Zhang H, Lou Z, Zhou JW, Zhu WG, Cong YS, Xu X. MRE11 UFMylation Promotes ATM Activation. Nucleic Acids Res. 2019 May 7;47(8):4124-4135.
4. Wang Q, Chen Q, Zhu L, Chen M, Xu W, Panday S, Wang Z, Li A, Røe OD, Chen R, Wang S, Zhang R, Zhou J. JWA regulates TRAIL-induced apoptosis via MARCH8-mediated DR4 ubiquitination in cisplatin-resistant gastric cancer cells.Oncogenesis. 2017 Jul 3;6(7):e353. doi: 10.1038/oncsis.2017.57. PMID: 28671676
5. Xu W, Chen Q, Wang Q, Sun Y, Wang S, Li A, Xu S, Røe OD, Wang M, Zhang R, Yang L, Zhou JW. JWA reverses cisplatin resistance via the CK2-XRCC1 pathway in human gastric cancer cells. Cell Death Dis. 2014 Dec 4;5:e1551.
6. Chen Y, Huang Y, Huang Y, Xia X, Zhang J, Zhou Y, Tan Y, He S, Qiang F, Li A, Røe OD, Li G, Zhou JW. JWA suppresses tumor angiogenesis via Sp1-activated MMP-2 and its prognostic significance in human gastric cancer.Carcinogenesis (2014) 35 (2): 442-451
7. Wang S, Wu X, Zhang J, Chen Y, Xu J, Xia X, He S, Qiang F, Li A, Shu Y, Røe OD, Li G, Zhou JW. CHIP functions as a novel suppressor of tumour angiogenesis with prognostic significance in human gastric cancer.Gut. 2013 Apr;62(4):496-508.
8. Wang S, Wu X, Chen Y, Zhang J, Ding J, Zhou Y, He S, Tan Y, Qiang F, Bai J, Zeng J, Gong Z, Li A, Li G, Røe OD, Zhou J. Prognostic and Predictive Role of JWA and XRCC1 Expressions in Gastric Cancer. Clin Cancer Res. 2012 May 15;18(10):2987-2996.
9. Bai J, Zhang JB, Wu J, Shen LL, Zeng JY, Ding JJ, Wu Y, Gong ZH, Li AP, Xu S, Zhou JW and Li G. JWA regulates melanoma metastasis by integrin avb3 signaling. advance online publication. Oncogene 2010, 29: 1227-1237.
10. Wang SY, Gong ZH, Chen R, Liu YR, Li AP, Li G, Zhou JW. JWA regulates XRCC1 and functions as a novel base excision repair protein in oxidative-stress-induced DNA single-strand breaks.Nucleic Acids Res. 2009 Apr;37(6):1936-50.