王虹,女,主任医师、教授、博士研究生导师、医学博士。江苏省人民医院原院长、党委书记。兼任国务院学位委员会学科评议组成员、江苏省人民政府参事、省政协常委、省科协常委、中国医院协会医院文化专业委员会主任委员、中国老年医学会舒缓医学分会主任委员、江苏省医师协会副会长,省抗衰老学会理事长,省医学会健康管理学分会主任委员。享受国务院政府特殊津贴,获国家卫生计生委“突出贡献中青年专家”称号。长期从事老年医学、呼吸系统疾病的临床诊治、科研和教学工作。主持并完成国家科技重大专项子课题等课题近十项,获国家新药发明专利一项,曾获国家科技进步三等奖、江苏省科技进步一等奖等奖项十余项。在国内外有影响的著名期刊上发表论文百余篇,其中SCI收录第一作者及通讯作者数十篇,参编专著十余部(本)。先后担任《国际呼吸》等十多种专业期刊主编或编委。
Email: hongwang@njmu.edu.cn
Tel: 025-83737024
研究方向
1. 呼吸系统疾病的临床诊治、科研和教学
2. 老年医学
3. 健康管理
主要科研项目
2019-2024 重组人IL-2免疫辅助治疗耐多药肺结核缩短病程及提高疗效的研究,国家科技重大专项(研究总负责)
2016-2018 医院的纵向医联体合作模式与运行管理机制研究,江苏省卫生厅开放课题(研究总负责)
2016-2021 初治涂阳肺结核病治疗新方案的研究(2015ZX10003001),国家科技重大专项(研究总负责)
2013-2018 以重组IL-2辅助治疗耐多药肺结核缩短病程及提高疗效的研究,十二五国家科技支撑计划(研究总负责)
2012-2015 江苏省呼吸病临床医学研究中心,临床医学研究中心(研究总负责)
2011-2013 江苏省药物临床研发平台建设(研究总负责)
2011-2014 呼吸病新药临床评价研究技术平台建设(研究总负责)
2010-2012 核糖体蛋白L22参与调控人肺动脉阻力血管平滑肌细胞异常增殖的分子机制研究(研究总负责)
2008-2010 缺氧性肺动脉高压易感基因及新型K-ATP开放剂埃他卡林的作用研究(研究总负责)
2009-2013 新型KATP开放剂埃他卡林治疗肺动脉高压的临床研究(研究总负责)
2008-2010 以重组IL-2和GM-CSF辅助治疗难治性肺结核缩短病及提高疗效的研究--2008zx10003-014,国家科技重大专项(研究总负责)
代表性论文
1. Wang JJ, Kong H, Xu J, Wang YL, Wang H*, Xie WP. Fasudil alleviates LPS-induced lung injury by restoring aquaporin 5 expression and inhibiting inflammation in lungs. J Biomed Res. 2019 Jun 4;33(3):156-163. doi: 10.7555/JBR.31.20170024.
2. Tan Q, Min R, Dai GQ, Wang YL, Nan L, Yang Z, Xia J, Pan SY, Mao H, Xie WP, Wang H*. Clinical and Immunological Effects of rhIL-2 Therapy in Eastern Chinese Patients with Multidrug-resistant Tuberculosis. Sci Rep. 2017 Dec 19;7(1):17854. doi: 10.1038/s41598-017-18200-5.
3. Ye LY, Hu S, Xu HE, Xu RR, Kong H, Zeng XN, Xie WP, Wang H*. The effect of tetrandrine combined with cisplatin on proliferation and apoptosis of A549/DDP cells and A549 cells. Cancer Cell Int. 2017 Mar 27;17:40. doi: 10.1186/s12935-017-0410-1. eCollection 2017.
4. Li N, Xie WP, Kong H, Min R, Hu CM, Zhou XB, Lu ZM, Ji XH, Wang H*. Enrichment of regulatory T-cells in blood of patients with multidrug-resistant tuberculosis. Int J Tuberc Lung Dis. 2015 Oct;19(10):1230-8. doi: 10.5588/ijtld.15.0148.
5. Wang YL, Kong H, Xie WP, Wang H*. Association of vitamin D-binding protein variants with chronic obstructive pulmonary disease: a meta-analysis. Genet Mol Res. 2015 Sep 9;14(3):10774-85. doi: 10.4238/2015.September.9.16.
6. Xu H, Li X, Ding W, Zeng X, Kong H, Wang H*, Xie W. Deguelin induces the apoptosis of lung cancer cells through regulating a ROS driven Akt pathway. Cancer Cell Int. 2015 Feb 25;15:25. doi: 10.1186/s12935-015-0166-4.
7. Kong H, Zeng XN, Fan Y, Yuan ST, Ge S, Xie WP, Wang H*, Hu G. Aquaporin-4 knockout exacerbates corticosterone-induced depression by inhibiting astrocyte function and hippocampal neurogenesis. CNS Neurosci Ther. 2014 May;20(5):391-402.
8. Xu H, Hou Z, Zhang H, Kong H, Li X, Wang H*, Xie W. An efficient Trojan delivery of tetrandrine by poly(N-vinylpyrrolidone)-block-poly(ε-caprolactone) (PVP-b-PCL) nanoparticles shows enhanced apoptotic induction of lung cancer cells and inhibition of its migration and invasion. Int J Nanomedicine. 2014;9:231-42.
9. Bi LQ, Zhu R, Kong H, Wu SL, Li N, Zuo XR, Zhou SM, Kou JP, Yu BY, Wang H*, Xie WP. Ruscogenin attenuates monocrotaline-induced pulmonary hypertension in rats. Int Immunopharmacol. 2013 May;16(1):7-16.
10. Yu Y, Xiao Y, Wang H, Li J, Zuo X, Wang H*, Xie W. Protective effect of nicorandil on hypoxia‑induced apoptosis in HPAECs through inhibition of p38 MAPK phosphorylation. Mol Med Rep. 2013 Mar;7(3):816-20.
11. Xia J, Wu X, Yang Y, Zhao Y, Fang M, Xie W, Wang H*, Xu Y. SIRT1 deacetylates RFX5 and antagonizes repression of collagen type I (COL1A2) transcription in smooth muscle cells. Biochem Biophys Res Commun. 2012 Nov 16;428(2):264-70.
12. Zuo XR, Wang Q, Cao Q, Yu YZ, Wang H, Bi LQ, Xie WP, Wang H*. Nicorandil prevents right ventricular remodeling by inhibiting apoptosis and lowering pressure overload in rats with pulmonary arterial hypertension. PLoS One. 2012;7(9):e44485.
13. Wang Q, Zuo XR, Wang YY, Xie WP, Wang H*, Zhang M. Monocrotaline-induced pulmonary arterial hypertension is attenuated by TNF-α antagonists via the suppression of TNF-α expression and NF-κB pathway in rats. Vascul Pharmacol. 2013 Jan;58(1-2):71-7.
14. Xue H, Sun K, Xie W, Hu G, Kong H, Wang Q, Wang H*. Etanercept attenuates short-term cigarette-smoke-exposure-induced pulmonary arterial remodelling in rats by suppressing the activation of TNF-a/NF-kB signal and the activities of MMP-2 and MMP-9. Pulm Pharmacol Ther. 2012 Jun;25(3):208-15.
15. Sun K, Xue H, Wang H, Wang Q, Zuo XR, Xie WP, Wang H*. The effects of siRNA against RPL22 on ET-1-induced proliferation of human pulmonary arterial smooth muscle cells. Int J Mol Med. 2012 Aug;30(2):351-7.
16. Zuo XR, Zhang R, Jiang X, Li XL, Zong F, Xie WP, Wang H*, Jing ZC. Usefulness of intravenous adenosine in idiopathic pulmonary arterial hypertension as a screening agent for identifying long-term responders to calcium channel blockers. Am J Cardiol. 2012 Jun 15;109(12):1801-6.
17. Xue H, Su J, Sun K, Xie W, Wang H*. Glutathione S-transferase M1 and T1 gene polymorphism and COPD risk in smokers: an updated analysis. Mol Biol Rep. 2012 Apr;39(4):5033-42.
18. Tan Q, Xie WP, Min R, Dai GQ, Xu CC, Pan HQ, Miao CD, Yang Z, Xu WG, Wang H*. Characterization of Th1- and Th2-type immune response in human multidrug-resistant tuberculosis. Eur J Clin Microbiol Infect Dis. 2012 Jun;31(6):1233-42.
19. Zuo X, Zong F, Wang H, Wang Q, Xie W, Wang H*. Iptakalim, a novel ATP-sensitive potassium channel opener, inhibits pulmonary arterial smooth muscle cell proliferation by downregulation of PKC-α. J Biomed Res. 2011 Nov;25(6):392-401.
20. Yang MX, Liu ZX, Zhang S, Jing Y, Zhang SJ, Xie WP, Ma L, Zhu CL, Wang H*. Proteomic analysis of the effect of iptakalim on human pulmonary arterial smooth muscle cell proliferation. Acta Pharmacol Sin. 2009 Feb;30(2):175-83.
21. Zhu Y, Zhang S, Xie W, Li Q, Zhou Y, Wang H*. Iptakalim inhibited endothelin-1-induced proliferation of human pulmonary arterial smooth muscle cells through the activation of K(ATP) channel. Vascul Pharmacol. 2008 Feb-Mar;48(2-3):92-9.
专著教材
《现代肺动脉高压治疗学》,江苏科学技术出版社,2007年,主编
《新编结核病防治300问》,东南大学出版社,2008年,主编
《临床诊断学》,高等教育出版社,2011年,编委
《医患沟通学》,人民卫生出版社,2003年,副主编
《临床抗菌药物合理使用提要》,江苏科学技术出版社,2010年,主编